To identify the catalytic residues of an enzyme structure, MEPI predicts catalytic residues based on the micro-environment and position information of residues. For more details about the method ...

MEPI server is only free for academic users. Other users are encouraged to contact us for permission.

Upload your structure file in PDB format:

NOTE:

Since MEPI was developed at the protein domain level, we advise that the PDB file you upload should be a single domain. If the file you upload contains multiple domains, it will be processed as a single domain and the performance may be lower than expected.

           File to Submit:      *

           Job Title:       *

           User E-Mail:        *

                      

Query your submitted job

           Job ID:       *

                      

In case you find MEPI useful, please cite:

Lei Han, Yong-Jun Zhang, Jiangning Song, Ming S.Liu and Ziding Zhang. Catalytic Residue Prediction Using a Novel Structural Feature that Integrates the Micro-environment and Geometrical Location Properties of Residues. PLos ONE 7(7):e41370.

Acknowledgement:

We sincerely thank Prof. Tal Pupko for providing Rate4Site program to calculate conservation score of each residue.